Category: Uncategorized

•  “In vivo evaluation of retinal neurodegeneration in patients with multiple sclerosis”: Tatrai E

  “In vivo evaluation of retinal neurodegeneration in patients with multiple sclerosis”: Tatrai E

  The circumpapillary RNFL thickness was significantly decreased in the non-affected eyes compared to controls group only in the temporal quadrant (p = 0.001) while it was decreased in the affected eyes of the MS patients in all quadrants compared to the non-affected eyes (p<0.05 in each comparison). The thickness of the total retina, RNFL, ganglion cell layer and inner plexiform layer complex (GCL+IPL) and ganglion cell complex (GCC, comprising the RNFL and GCL+IPL) in the macula was significantly decreased in the non-affected eyes compared to controls (p<0.05 for each comparison) and in the ON-affected eyes compared to the non-affected eyes (p<0.001 for each comparison). The largest area under the ROC curve (0.892) was obtained for the weighted mean thickness of the GCC. The EDSS score showed the strongest correlation with the GCL+IPL and GCC thickness (p = 0.007, r = 0.43 for both variables).

  January 21, 2025

  ---

• “Progression of retinal ganglion cell loss in multiple sclerosis is associated with new lesions in the optic radiations”: Klistorner A et al

   “Progression of retinal ganglion cell loss in multiple sclerosis is associated with new lesions in the optic radiations”: Klistorner A et al

  – Significant tRNFL thickness reduction was observed over the 3-year follow-up period at a relatively constant rate (1.02 μm/year). Thinning of tRNFL fibers was more prominent in younger patients (P = 0.01). The tRNFL loss was associated with new MRI lesions in the optic radiations (ORs). There was significantly greater tRNFL thinning in patients with new lesional activity in the ORs compared with patients with new lesions outside the ORs (P = 0.009).- This study supports the notion that retrograde transneuronal degeneration caused by OR lesions might play a role in progressive retinal nerve fiber layer loss. In addition, the results of the study also indicate that the disease-related neurodegenerative changes in the retina start much earlier than the clinical diagnosis of MS.

  January 21, 2025

  ---

• “Association of retinal and macular damage with brain atrophy in multiple sclerosis”: Dorr J et al

   “Association of retinal and macular damage with brain atrophy in multiple sclerosis”: Dorr J et al

  -We found that both RNFLT (p = 0.019, GEE) and TMV (total macular volume) (p = 0.004, GEE) associate with BPF (brain parenchymal fraction). RNFLT was furthermore linked to the disease duration (p<0.001, GEE) but neither to disease severity nor patients’ age. Contrarily, BPF was rather associated with severity (p<0.001, GEE) than disease duration and was confounded by age (p<0.001, GEE). TMV was not associated with any of these parameters. Thus, we conclude that in RRMS patients with relatively short disease duration and rather mild disability RNFLT and TMV reflect brain atrophy and are thus promising parameters to evaluate neurodegeneration in MS.

  January 21, 2025

  ---

• “Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis”: Gordon-Lipkin E et al

  “Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis”: Gordon-Lipkin E et al

  -In multiple sclerosis (MS), retinal nerve fiber layer thickness is associated with brain parenchymal fraction and CSF volume. These data suggest that quantification of axonal thickness in the retina by optical coherence tomography (OCT) provides concurrent information about MRI brain abnormality in MS.

  -Minimum RNFL thickness and subject age together predict 21% (p = 0.005) of the variance in BPF in all patients with MS and 43% (p = 0.003) of the variance in BPF in the subgroup with relapsing remitting MS (RRMS; n = 20). The partial correlation coefficient between BPF and minimum RNFL thickness, controlling for age, is 0.46 (p = 0.003) in all patients with MS and 0.69 (p = 0.001) in patients with RRMS. These associations are driven by CSF volume but not by gray or white matter volume. There is no significant association of these variables among controls.

  January 21, 2025

  ---

• “Retinal degeneration in primary-progressive multiple sclerosis: A role for cortical lesions?”: Petracca M et al

   “Retinal degeneration in primary-progressive multiple sclerosis: A role for cortical lesions?”: Petracca M et al

  -RNFL thinning was associated with thalamus and visual cortex volume (respectively, p = 0.01 and p < 0.05). In addition to thalamic volume, GCIPL thinning was associated with CLs and intracortical lesion number and volume, leucocortical lesion volume (all p ⩽ 0.05) while MV decrease was associated with CLs volume ( p = 0.05) and intracortical lesion number and volume ( p < 0.05).

  -Our results suggest that RNFL thinning and GCIPL thinning/MV decrease may be explained by alternative mechanisms including retrograde trans-synaptic degeneration and/or a common pathophysiologic process affecting both the brain with CLs and the retina with neuronal loss.

  January 21, 2025

  ---

• “The association between retinal nerve fibre layer thickness and corpus callosum index in different clinical subtypes of multiple sclerosis”: Vedat Cilingir et al

  “The association between retinal nerve fibre layer thickness and corpus callosum index in different clinical subtypes of multiple sclerosis”: Vedat Cilingir et al-There is a correlation between the thickness of the RNFL and CCI (corpus callosum index) values in MS patients with no history of ON, which suggests that OCT might be a suitable marker for neurodegeneration in MS clinical trials.

  January 21, 2025

  ---

•  “Retinal Layer Segmentation in Patients with Multiple Sclerosis Using Spectral Domain Optical Coherence Tomography”: Elena Garcia-Martin, PhD

   “Retinal Layer Segmentation in Patients with Multiple Sclerosis Using Spectral Domain Optical Coherence Tomography”: Elena Garcia-Martin, PhD

  -The retinal nerve fiber layer and ganglion cell layer thicknesses were inversely correlated with the functional disability score in patients with MS. 

  -Reduction of the ganglion cell and inner plexiform layers predicted greater axonal damage in patients with MS.

  January 21, 2025

  ---

• “Disease course heterogeneity and OCT in multiple sclerosis”:  LJ Balk, P Tewarie

  “Disease course heterogeneity and OCT in multiple sclerosis”:  LJ Balk, P Tewarie-Primary progressive patients showed relative preservation of inner retinal layers, compared to the relapsing onset MS types. Only in MS eyes without optic neuritis did patients with typical MS show more severe thinning of the inner retinal layers (RNFL to INL) compared to patients with a benign disease course, even after an average disease course of 20 years.

  January 21, 2025

  ---

•  “Degeneration of retinal layers in multiple sclerosis subtypes quantified by optical coherence tomography”: Albrecht P et al

  “Degeneration of retinal layers in multiple sclerosis subtypes quantified by optical coherence tomography”: Albrecht P et al

  -Even without a history of optic neuritis, all MS subgroups had significant thinning of the peripapillary retinal nerve fibre layer, the paramacular retinal thickness and the retinal ganglion cell- and inner plexiform layer. Only in primary progressive MS was the inner nuclear layer significantly reduced.

  -Our findings indicate a primary retinal pathology involving the inner nuclear layer in primary progressive MS. Results in eyes without history of optic neuritis suggest possible subclinical episodes of optic neuritis or retrograde trans-synaptic degeneration of retinal ganglion cells and their axons.

  January 21, 2025

  ---

• “Benign multiple sclerosis is associated with reduced thinning of the retinal nerve fiber and ganglion cell layers in non-optic-neuritis eyes”: Huang-Link YM et al

  “Benign multiple sclerosis is associated with reduced thinning of the retinal nerve fiber and ganglion cell layers in non-optic-neuritis eyes”: Huang-Link YM et al

  –Results: The RNFL and GCL were significantly thinner in eyes previously affected by ON, irrespective of the type of MS (i.e., BMS (benign MS) or RRMS), than in HCs. Significant thinning of the GCL was also observed in non-ON RRMS (and not non-ON BMS (benign MS)) compared to HCs. Correspondingly, a significant association between disease duration and thinning rates of the RNFL and GCL was observed only in non-ON RRMS (-0.54±0.24 and -0.43±0.21 μm/year, mean±SE; p<0.05 for both), and not in non-ON BMS (benign MS) (-0.11±0.27 and -0.24±0.24 μm/year).-Conclusions: The RNFL and GCL were thinner in both ON- and non-ON MS, but the change was more pronounced in ON MS, irrespective of the MS subtype studied herein. GCL thinning and the thinning rate of both the GCL and RNFL were less pronounced in non-ON BMS than in non-ON RRMS. These findings may help to predict the course of BMS (benign MS)

  January 21, 2025

  ---