Category: Uncategorized

• “Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes”: Dalton CM et al

  1. “Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes”: Dalton CM et al

  -progressive grey matter, but not white matter, atrophy is seen in the earliest clinically observable stages of relapse onset MS and this is only moderately related to lesion burden

  -in those who developed MS (from CIS), the mean decrease in grey matter fraction volume was significantly larger than in the combined lesion-positive and lesion-negative CIS subjects

  January 21, 2025

  ---

• “Transected neurites, apoptotic neurons and reduced inflammation in cortical multiple sclerosis lesions”: Peterson JW

  1. “Transected neurites, apoptotic neurons and reduced inflammation in cortical multiple sclerosis lesions”: Peterson JW

  -apoptotic neurons were increased significantly in demyelinated cortex compared to myelinated cortex

  -demyelination, axonal transection, dendritic transection and apoptotic loss of neurons in the cerebral cortex contribute to neurological dysfunction in MS

  January 21, 2025

  ---

• “Neocortical, neuronal, synaptic and glial loss in multiple sclerosis”: Wegner C et al

  1. “Neocortical, neuronal, synaptic and glial loss in multiple sclerosis”: Wegner C et al

  -nonlesional neocortex did not show significant changes in neuronal, glial or synaptic density

  -neocortical neuronal and glial degeneration is significant in MS 

  -synaptic loss was particularly striking in the neocortical lesions

  January 21, 2025

  ---

• “Inflammatory demyelination is not central to the pathogenesis of multiple sclerosis”: Bruck W

  1. “Inflammatory demyelination is not central to the pathogenesis of multiple sclerosis”: Bruck W

  -damage may be propagated throughout the nervous system by anterograde Wallerian, retrograde or transynaptic degeneration

  -cumulative tissue loss in the grey and white matter, esp of axons, is important and probably the principal determinant of accumulation of irreversible neurological disability and of conversion to a progressive disease course

  -a generalized, diffuse neurodegenerative process plays an important role in the pathogenesis of MS

  -persistent low-level axonal damage in active plaques and diffuse axonal and neuronal loss throughout the nervous system

  January 21, 2025

  ---

• “Putting magnetic resonance spectroscopy studies in context: axonal damage and disability in multiple sclerosis” by Matthews PM et al

  1. “Putting magnetic resonance spectroscopy studies in context: axonal damage and disability in multiple sclerosis” by Matthews PM et al

  -distinct correlations between these axonal changes and disability

  January 21, 2025

  ---

• “Longitudinal brain volume measurement in multiple sclerosis: rate of brain atrophy is independent of the disease subtype”: Kalkers NF et al

  1. “Longitudinal brain volume measurement in multiple sclerosis: rate of brain atrophy is independent of the disease subtype”: Kalkers NF et al

  -decrease in parenchymal fraction was not different between subtypes

  -increase in ventricular fraction tended to be larger in patients with SPMS vs patients w PPMS

  -marginal associations found between clinical determinants and rate of brain atrophy

  -annualized increase in the ventricular fraction was correlated with age and duration of symptoms: younger patients (mainly patients w RRMS who have a limited disability) displayed a larger increase in ventricular fraction compared with older patients

  -the relentless loss of tissue occurring in MS is not restricted to later (progressive) phases of the disease, thereby stressing the need for early neuroprotective treatment in MS

  January 21, 2025

  ---

• “Two-year follow-up study of primary and transitional progressive multiple sclerosis”: Ingle GT et al

  1. “Two-year follow-up study of primary and transitional progressive multiple sclerosis”: Ingle GT et al

  -in PPMS, significantly higher lesion loads were found in those who presented with non-spinal cord syndromes when compared to spinal cord presentation and there was a trend to greater brain atrophy in those who deteriorated clinically over the course of the study compared to those who remained stable

  -significant cord atrophy was only seen in those with a spinal cord presentation

  January 21, 2025

  ---

• “Grey matter damage predictors the evolution of primary progressive multiple sclerosis at 5 years”: Rovaris M et al

  1. “Grey matter damage predictors the evolution of primary progressive multiple sclerosis at 5 years”: Rovaris M et al

  -baseline EDSS score and average GM MD (mean diffusivity) were independent predictors of subsequent clinical deterioration

  -a lower level of disability and a more severe GM damage identify PP MS patients with an increased risk of disease progression over the subsequent 5 years

  January 21, 2025

  ---

• “One year follow up study of primary and transitional progressive multiple sclerosis” by Stevenson VL et al

  1. “One year follow up study of primary and transitional progressive multiple sclerosis” by Stevenson VL et al

  -only primary progressive group showed evidence of significant brain atrophy

  January 21, 2025

  ---

• “Focal thinning of the cerebral cortex in multiple sclerosis:” Sailer M et al

  1. “Focal thinning of the cerebral cortex in multiple sclerosis:” Sailer M et al

  -mean overall thickness of cortical ribbon reduced in MS patients v controls

  -significant main effects for disability, disease duration, T2 and T1 lesion volumes

  -distinct distribution of significant focal thinning of the cerebral cortext in addition to diffuse cortical atrophy

  -focal cortical thinning in frontal and temporal regions was observed, even early in the disease course or in patients with mild disease

  -patients with longstanding disease or severe disability presented additionally with focal thinning of the motor cortex area

  -focal cortical thinning and an overall reduction of the cortical thickness with disease progression

  January 21, 2025

  ---