Multiple Sclerosis Research Repository


Beware Headlines Like This: “These two drugs may be the best to treat nerve pain”

From: https://knowridge.com/2025/04/these-two-drugs-may-be-the-best-to-treat-nerve-pain/?fbclid=IwY2xjawJwh9JleHRuA2FlbQIxMQABHmcKSXHCW0r1cEQPghf2ZnXmzo5rDTesC292mcPQu9GMfdhHFswjexVl4eCo_aem_Ti-ImMUz3YZc8aLp8y04Wg

-About 25% of patients taking nortriptyline felt real relief from their pain.

-Duloxetine was close behind, with 23% of patients finding it helpful 

-Pregabalin had the lowest success rate, helping only 15% of patients

-mexiletine had the highest quit rate—more than half the patients (58%) stopped taking it, possibly because of side effects or lack of improvement

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