Multiple Sclerosis Research Repository

1. “Effect of immunomodulatory medication on regional gray matter loss in relapsing-remitting multiple sclerosis-A longitudinal MRI study”: Kerstin Bendfeldt et al

-Results suggest differences in the dynamics of regional GM volume atrophy in differentially treated or untreated RRMS patients

-patients without immunomodulatory medication showed no significant cortical GM volume changes 

-over all unmedicated patients with RRMS, no significant cortical GM volume changes were found

-the insula

-those interconnected areas might be prone to be affected by axonal degeneration in the cerebral white matter

-increasing degeneration of those lesions (periventricular) could interrupt tracts that originate from or project to prefrontal, cingulate, and association areas

-Khan et al showed that treatment with GA (glatiramer acetate) leads to axonal metabolic recovery and protection from sub-lethal axonal injury indicating the potential neuroprotective effects of GA

-GM (and not WM) atrophy is associated with whole brain atrophy