Multiple Sclerosis Research Repository

1. “Regional brain atrophy development is related to specific aspects of clinical dysfunction in multiple sclerosis”: Jasperse B et al

-worse EDSS change-score and worse follow-up EDSS were related to atrophy development of periventricular and brainstem regions and right-sided parietal, occipital and temporal regions

-worse PASAT at follow up was significant related to atrophy of the ventricles

-a worse TWT change-score and worse follow-up TWT were exclusively related to atrophy around the ventricles and of the brainstem

-worse HPT change-score and worse follow-up HPT of either arm were significantly related to the atrophy of widely distributed peripheral regions as well as atrophy of periventricular and brainstem regions

-findings suggest that decline in ambulatory function is related to atrophy of central brain regions exclusively whereas decline in neurologically more complex tasks for coordinated hand function is related to atrophy of both central and peripheral brain regions