Multiple Sclerosis Research Repository

1. “Predicting cognitive decline in multiple sclerosis: a 5-year follow-up study” by Anand J C Eijlers et al

-at baseline, patients with MS had a mean disease duration of 14.8 years and 4% were classified as cognitively impaired

-28% demonstrated cognitive decline during follow up, w higher frequencies in progressive vs RRMS: SPMS (55%); PPMS (53%); and RRMS (21%)

-cortical grey matter as the only significant MRI predictor of cognitive decline

-integrity loss of anterior thalamic radiation, lesions in the superior longitudinal fasciculus and temporal atrophy as significant MRI predictors for cognitive decline

-disease stage specific regressions showed that cognitive decline in early RRMS was predicted by white matter integrity damage while cognitive decline in late RRMS and progressive MS was predicted by cortical atrophy

-patients w more severe structural damage at baseline and especially cortical atrophy are more prone to suffer from cognitive decline