Multiple Sclerosis Research Repository

 “Multiple Sclerosis is Primarily a Neurodegenerative Disease” by Abhijit Chaudhuri

-”The primary role of inflammation in the human disease (MS) is presumed, rather than proven”

-”It is likely that the very modest inflammatory changes present in MS plaques represent the secondary effect of myelin injury and degradation triggered by a yet unknown process of metabolic stress.”

-”there is significant loss of brain volume that occurs irrespective of the severity of inflammatory process”

-”no anti-inflammatory treatment has ever been shown to reverse progressive disability from degeneration of neurons, axons and synapses in the central nervous system that characterize the disease”

-”changes occur often at sites distant to inflammatory changes and lymphocytic infiltrates”

-”oligodendrocyte apoptosis and microglial activation has been reported in acute MS in the absence of lymphocytes and macrophage activation”

-”There is no firm evidence that inflammatory changes are directed towards specific targets and there is no target antigen or pathogenic antibody in MS”

-”In all likelihood, disease pathogenesis and disease progression in MS are metabolically influenced and are controlled by the oxidative stress in genetically and environmentally susceptive individuals”

-”Anti-inflammatory therapy may have a marginal therapeutic benefit in neurodegenerative diseases by limiting the process of oxidative injury and the experience of immunotherapy in MS does not prove its causation”