Multiple Sclerosis Research Repository

1. “Multiple Sclerosis: Current and Emerging Disease-Modifying Therapies and Treatment Strategies”: Dean M. Wingerchuk, MD, MSc, FRCP(C) et al

– Two of the greatest are lack of therapies that convincingly slow or halt progressive forms of the disease

-Furthermore, epidemiologic studies124 and therapeutic studies in established SPMS125 suggest that there may be an important dissociation between the inflammatory and neurodegenerative phases of MS. In other words, successful elimination of early inflammation may not necessarily translate into an effect on degenerative progression, the mechanisms of which could be operative even early in relapsing disease.