Multiple Sclerosis Research Repository

1. “Longitudinal brain volume measurement in multiple sclerosis: rate of brain atrophy is independent of the disease subtype”: Kalkers NF et al

-decrease in parenchymal fraction was not different between subtypes

-increase in ventricular fraction tended to be larger in patients with SPMS vs patients w PPMS

-marginal associations found between clinical determinants and rate of brain atrophy

-annualized increase in the ventricular fraction was correlated with age and duration of symptoms: younger patients (mainly patients w RRMS who have a limited disability) displayed a larger increase in ventricular fraction compared with older patients

-the relentless loss of tissue occurring in MS is not restricted to later (progressive) phases of the disease, thereby stressing the need for early neuroprotective treatment in MS