Multiple Sclerosis Research Repository

1. “Localization of grey matter atrophy in early RRMS: A longitudinal study”: Audoin B et al

-during the follow-up period, significantly greater atrophy occurred in both thalami and the right lateral prefrontal cortex of MS patients v controls

-by year 2: GM atrophy in the thalami of MS patients v controls

-rate of thalamic atrophy in MS subjects correlated w changes in EDSS during the follow up period

-this study suggest that early in the clinical course of RRMS, the thalamic atrophy is more consistently apparent than regional cortical atrophy