Multiple Sclerosis Research Repository

1. “Inflammatory demyelination is not central to the pathogenesis of multiple sclerosis”: Bruck W

-damage may be propagated throughout the nervous system by anterograde Wallerian, retrograde or transynaptic degeneration

-cumulative tissue loss in the grey and white matter, esp of axons, is important and probably the principal determinant of accumulation of irreversible neurological disability and of conversion to a progressive disease course

-a generalized, diffuse neurodegenerative process plays an important role in the pathogenesis of MS

-persistent low-level axonal damage in active plaques and diffuse axonal and neuronal loss throughout the nervous system