Multiple Sclerosis Research Repository

1. “Quantitative Limbic System Mapping of Main Cognitive Domains in Multiple Sclerosis” by Zafer Keser et al

-fornix and cingulum/cingulate cortices were found to be the strongest correlates of CI in MS

2. Tau seeding starts early in the entorhinal cortex (S Kaufman et al: “Tau Seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART”

-neurofibrillary tangles of phosphorylated tau is preceded by tau aggregation in the transentorhinal and entorhinal cortices

3. “Extensive Hippocampal Demyelination in Multiple Sclerosis” (Journal of Neuropathology and Experimental Neurology, Volume 66, Issue 9, September 2007, Pages 819-827)

-crucial role for hippocampal pathology in MS

-the cornu ammonis 2 subregion and the hilus of the dentate gyrus were consistently spared in isolated intrahippocampal lesions (frequently found); microglial activation was rare in these

-results indicate that hippocampal demyelination is frequent and extensive in MS