Multiple Sclerosis Research Repository

1. “Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes”: Dalton CM et al

-progressive grey matter, but not white matter, atrophy is seen in the earliest clinically observable stages of relapse onset MS and this is only moderately related to lesion burden

-in those who developed MS (from CIS), the mean decrease in grey matter fraction volume was significantly larger than in the combined lesion-positive and lesion-negative CIS subjects