Multiple Sclerosis Research Repository

1. “Correlates of MS disability assessed in vivo using aggregates of MR quantities”: Mainero C et al

-correlations between the EDSS score and each of the MR quantities take in isolation were not significant, with the exception of the correlation between EDSS and the NAA/creatine ratio

-3 of the composite MR scores computed using regression models were strongly correlated with the EDSS scores

– the model that included T2 and T1 lesion volumes and brain D (diffusivity) explained 34% of the EDSS variance

-the model that included T2 and T1 lesion volumes and brain N-acetylaspartate/creatine ratio explained 36% of the EDSS variance

-the model that included T1 lesion volume, brain diffusivity, and brain N-acetylaspartate/creatine ratio explained 53% of the EDSS variance