Multiple Sclerosis Research Repository

1. “Cognitive impairment in early-onset multiple sclerosis: pattern, predictors and impact on everyday life in a 4-year follow up”: Amato MP et al

-cognitive and neurological deficits appear not to develop in parallel

-cognitive dysfunctional proves to be a predictor of handicap in everyday life, even in patients in the incipient phase of MS

-a patient’s initial disability level predicted decreased performance on only 4/13 cognitive variables and disease duration did so on only 2/13

-extent of intellectual decline on initial testing, initial disability level and progressive course were independent determinants of handicap in a patient’s work and social activities