Multiple Sclerosis Research Repository

 “Association of retinal and macular damage with brain atrophy in multiple sclerosis”: Dorr J et al

-We found that both RNFLT (p = 0.019, GEE) and TMV (total macular volume) (p = 0.004, GEE) associate with BPF (brain parenchymal fraction). RNFLT was furthermore linked to the disease duration (p<0.001, GEE) but neither to disease severity nor patients’ age. Contrarily, BPF was rather associated with severity (p<0.001, GEE) than disease duration and was confounded by age (p<0.001, GEE). TMV was not associated with any of these parameters. Thus, we conclude that in RRMS patients with relatively short disease duration and rather mild disability RNFLT and TMV reflect brain atrophy and are thus promising parameters to evaluate neurodegeneration in MS.