Multiple Sclerosis Research Repository

1. “Relating neocortical pathology to disability progression in multiple sclerosis using MRI”: Chen JT et al

1. “Relating neocortical pathology to disability progression in multiple sclerosis using MRI”: Chen JT et al

-average higher rate of apparent loss in cortical grey matter (CGM) thickness across the whole brain in the group that progressed over the interscan interval vs the group that remained stable; this difference was detected w regional measures in parietal and precentral cortex

-the group of MS patients whose disability progressed showed a significant decrease in GM/WM interface integrity compared to the stable group

-the results suggest that progression of disability in MS is associated with the progression of MRI-detectable cortical pathology